Aspirin increases bleeding risk in older stroke patients: Study

Aspirin increases bleeding risk in older stroke patients: Study

Aspirin increases bleeding risk in older stroke patients: Study

PARIS: The daily use of aspirin in the long term to prevent blood clots in very elderly patients an increased risk of severe or fatal internal bleeding, researchers said Wednesday.

The anti-heartburn drug would allow people age 75 and older to maintain the preventive benefits of aspirin and avoid its dangerous side effects, published in the medical journal The Lancet.

Even in people with no history of heart problems or stroke, the risk of gastrointestinal bleeding increases with the age of aspirin users, other research has shown.

About half of adults over 75 in the US And Europe take small doses of aspirin every day – from 75 to 150 milligrams – or other inhibitors of coagulation drugs.
A normal dose for a headache is 325 to 600 mg.

Continuous treatment with these drugs is especially recommended for patients who have had a heart attack or stroke.

But the clinical evidence underlying these recommendations mainly involved patients under age 75 who had taken aspirin for a few years.

Therefore, how the risk of bleeding can increase with age was largely unknown.
For more information, Peter Rothwell of the University of Oxford led a team of researchers in reviewing the medical records of more than 3000 patients who had a heart attack or stroke and took daily aspirin or its equivalent for many years .

Half of the patients were 75 years or older at the beginning of the study period.
Over the next decade, 314 patients were admitted to hospital for bleeding.

The risk that this has increased significantly with the age of patients younger than 65 years, the annual hospitalization rate due to bleeding was 1.5 percent; For patients aged 75-84, the rate rose to 3.5%; And 85, it was five percent.

Hemorrhagic risks become crippling or lethal, while lower, increasing by approximately the same proportions in different age groups.

“We have long known that aspirin increases the risk of bleeding in older patients,” Rothwell said in a statement. “But our study allows us to better understand the size of the increase in risk and the severity of the consequences.”

Researchers suggest that proton pump inhibitors (PPI) – a type of anti-heartburn medication – can reduce bleeding in the upper gastrointestinal tract by as much as 90 percent.

“There is evidence that long-term use of PPI may have small risks,” Rothwell said.
However, “the new data should reassure the benefits of the use of advanced age PPIs are greater than the risks.”

Treatment programs should be reviewed every three to five years in very advanced patients taking aspirin and the IPP together, the authors said.
Several experts not involved in the study praised its methodology and its approved conclusions.

“It is clear from the data presented that – in over 75 years – PPI with aspirin was associated with a lower likelihood of bleeding,” said Tony Fox, a professor in Pharmaceutical Medicine Group at King College London.

Irregular sleep tied to worse grades

Irregular sleep tied to worse grades

Irregular sleep tied to worse grades

By Marilynn Larkin

(Reuters Health) – College students who endormissent and get up at different times of the week may affect their academic performance, according to a US study.

Consistency – go to bed and wake up at about the same time every day, including weekends – related to better average (GPA) among study students, researchers have revealed.

“College students who slept during the cold during the week and slept on the weekend had poorer scores than those whose schedules were more consistent,” said lead author Dr. Charles Czeisler, director of the Sleep Institute of Sleep Boston Brigham and Women’s Hospital. Reuters Health by email.

Importantly, it was not important to know how much students dream globally. Sleep time, by itself, could predict poor school performance, even if students were able to sleep at night with naps during the day, according to results published in Scientific Reports.

Czeisler and his colleagues studied the students 61 full time 18 to 24 years for 30 days. Students completed sleep logs, and the researchers used the Sleep Consistency Index (SRI), a tool that was developed to evaluate students’ sleep habits.

The index is scaled so that a person who sleeps and wakes up at exactly the same time each day scores 100, and someone who sleeps and wakes up two random notes 0.

Those who scored at the highest 20 percent were classified as regular sleepers and those who scored at 20 percent were irregular sleepers.

Both groups averaged about seven hours of sleep per day, although irregular dorsels reported lower sleep quality.

Regular sleepers slept 55 percent of the “clock night” – the hours between 10 in the morning. 10 hours – and only 1 percent of clock day, while irregular sleepers had slept, 42 percent of night and 11 percent of clock day.

As a result, irregular transverse experienced much less daylight and relatively light at night, which caused a delay in secretion of the hormone from the sleep hormone in the body, according to the researchers.

These differences have led to a change in the biological clock in the irregular crosses equivalent to the western travelers for almost three hours Czeisler said, which may explain their underachievement academic.

“For students whose sleep and wakefulness were incompatible, courses and exams scheduled for 8 hours out at 5 am – a time when cognitive performance deteriorates,” he said.

Greater regularity of sleep was associated with a better average. Any 10-point increase in the sleep regularity index was associated with an average increase of 0.10 points in the GPA. At the end of the study, the uneven sleepers score an average of 3.24 on a possible 4.0, and the average sleepers average 3.72.

The study does not prove that irregular sleep leads to poorer academic performance, researchers have pointed out, but this could be a sign of other daily habits that interfere with how students can do in college.

Increasing exposure to daylight and reducing exposure to laptops and other light-emitting devices before bedtime can improve sleep regularity, suggesting that.

Sleep specialist Dr. Rafael Pelayo of Stanford in California Sleep Medicine Center told Reuters Health that although it is possible that some people deal better with sleep deprivation than others, many students may have been below and not giving themselves account.

“I compare it to a race car,” Pelayo said. “The manufacturer can recommend high octane gas, but they can put the cheap gas and if you are stuck in traffic, you will not notice the difference. But if you put on a racetrack, you will ask the real question is. “? Could you take better academic results if you have a better quality of sleep ”

In general, students say when they go to bed or wake up depends on the day it is. When they are at different times every other day and at the weekend, Pelayo pointed out, “The brain is thrown. It is as always to be undone – you are never at your best.